Postdoc Position in Detection and Quantification of Rnas and Their Modifications From Long Read Sequencing Data

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**Postdoc Position in Detection and Quantification of RNAs and Their Modifications from Long Read Sequencing Data**
- (2500000Z) **_
Commitment & contract:_**_ collaboration contract_ **_ Step into a world of endless possibilities, together let’s leave something for the future!_** At IIT, we are committed to advancing human-centered Science and Technology to address the most urgent societal challenges of our era. We foster excellence in both fundamental and applied research, spanning fields such as neuroscience and cognition, humanoid technologies and robotics, artificial intelligence, nanotechnology, and material sciences, offering a truly interdisciplinary scientific experience. Our approach integrates cutting-edge tools and technology, empowering researchers to push the limits of knowledge and innovation. With us, your curiosity will know no bounds. We are dedicated to providing equal employment opportunities and fostering diversity in all its forms, creating an inclusive environment. We value the unique experiences, knowledge, backgrounds, cultures, and perspectives of our people. By embracing diversity, we believe science can achieve its fullest potential. **THE ROLE** The **_GENOMIC SCIENCE_**_ _Research Unit is coordinated by Dr. Francesco Nicassio, who has extensive experience in **_Genomics_**_ and _**_Non-Coding RNA biology_**_._ The lab is engaged in a number of projects in areas of cancer genomics, development and stem cells focusing on the role of noncoding RNA transcripts. Importantly,



our research activity is based on the integration of **Experimental models** with **Computational methodologies**, pointing out the reciprocal regulation of coding and non-coding RNAs. Representative publications can be found here: - RNA modifications detection by comparative Nanopore direct RNA sequencing - **Nat Commun.** 2021 doi.org/10.1038/s41467-021-27393-3
- Nanopore ReCappable sequencing maps SARS-CoV-2 5′ capping sites and provides new insights into the structure of sgRNAs - **Nucleic Acid Res**. 2022 doi.org/10.1093/nar/gkac144
- Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing - **Brief Bioinform.** 2024 doi: 10.1093/bib/bbae001 PMID: 38279646
- Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome - **Mol Ther Nucleic Acids.**2023 doi.org/10.1016/j.omtn.2023.102052 PMID: 38028201 Within the team, your **main responsibilities** will be: - Developing computational methods and analytical strategies to characterize non-coding RNA biology and RNA modifications in a broad range of biological contexts, such as regulation of epigenetic regulation, gene expression control,



biogenesis and maturation of microRNAs and mechanisms of cancer progression and chemo-resistance;
- Coordinating and co-supervising junior members of the lab, participating to meetings and being involved in disseminating results from the Research Unit **ESSENTIAL REQUIREMENTS**
- PhD degree in a natural sciences discipline, such as Biology, Biotechnology, Mathematics, Physics, or similar;
- Documented experience in genomics, bioinformatics and scientific programming in R or Python;
- Good data analysis skills and a basic understanding of statistics;
- Ability to properly report and organize data;
- Good command in spoken and written English;
- Team-working ability;
- High motivation to learn;
- Experience on Nanopore sequencing. **ADDITIONAL SKILLS**
- Good level of knowledge on the biology of RNA modifications;
- Experience with bioinformatics workflow management tools such as Nextflow or SnakemakeGood communication skills;
- Strong problem-solving attitude;
- Spirit of innovation and creativity;
- Ability to work in a challenging and international environment;
- Ability to work independently and collaboratively in a highly interdisciplinary environment. **COMPENSATION PACKAGE**
- Competitive salary package for international standards;
- Private health care coverage;
- Wide range of staff discounts;
- Application’s deadline: March 4_th_ 2025_ **Primary Location** MILANO SEMM **Job** Postdoc **Organization** Genomic Science **Job Posting** Feb 17, 2025, 4:06:50 AM

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