Research assistant in CRISPR‑engineered cellular models of genetic disorders
Pubblicato il 05-08-2026 - Iigm - Italian Institute For Genomic Medicine in Italia
ph3Offer Description /h3 pbIIGM /b is located at the bFPO IRCCS Candiolo Cancer Institute /b, Candiolo, Turin – Italy. The main goal of the institute is to foster and develop excellence in research and education, with special reference to cancer biology and cancer biomarker discovery. The institute provides high-level scientific education for students and post‑doctoral fellows, and access to state‑of‑the‑art research facilities and international networks. /p pbGender Equality Plan /b: diversity is our legacy and our future. Be part of it. At bIIGM /b diversity is an integral part of our culture and identity and for this we have adopted a plan for gender equality (GEP). We promote diversity and inclusion because we recognize that they are a source of strength and competitive advantage. /p pbPosition /b /p pThe bChemical Biology Lab /b at the Italian Institute for Genomic Medicine (IIGM) is seeking highly motivated candidates at all levels of seniority (pre‑doc, postdoc) to work in high‑content imaging and analysis with a focus on cell‑to‑cell heterogeneity and phenotypic variability in membrane trafficking. The laboratory investigates key aspects of Rab GTPases and their involvement in hereditary genetic diseases. The project aims to generate cellular model of steroid‑resistant nephrotic syndrome (SRNS) disease and perform genotype‑phenotype correlation analysis using molecular and computational tools developed in the lab. By integrating phenotypic mapping with biochemical and genetic information, we seek to elucidate the biological functions of rare genetic variants causing SRNS. The Institute provides state‑of‑the‑art genomics, single‑cell genomics sequencing platforms and high‑content imaging platforms.
/p pbResponsibilities /b /p ul liGenerate isogenic HK‑2 cell lines harbouring genetic mutations causing SRNS disease. /li liPerform immunostaining of Rab GTPase and other proteins involved in intracellular trafficking. /li liPerform biochemical experiments on Rab GTPase regulators. /li liConduct image acquisition using automated microscopy systems. /li liPerform image data analysis of high‑dimensional dataset. /li liContribute to ongoing research group activities and collaborative projects. /li /ul pbOffered contract /b: Coordinated and Continuous Collaboration contract (Co.Co.Co.) on a project basis, duration to be defined. Competitive remuneration based on the candidate’s personal qualifications. /p h3Requirements /h3 pEducation Level: Bachelor Degree or equivalent in biotechnology, biology, medicine, chemical biology, pharmacy or a related field. /p ul li1 year experience in at least one of the following subjects: ul liGeneration of knock‑in CRISPR/Cas9 edited human cells. /li liHigh‑content imaging and data analysis. /li liMammalian tissue culture (cells and/or organoids). /li /ul /li liCuriosity and active learning. /li liCritical thinking and problem‑solving. /li liTime management. /li liAdaptability and flexibility. /li liEffective communication in cross‑cultural environments. /li /ul pLanguages /p ul liEnglish – Excellent. /li liItalian – Basic. /li /ul pYears of research experience: 1‑4 years. /p h3Additional Information /h3 pInterested candidates should include /p ul liResearch proposal (for postdoc applicants only). /li liCertificates, transcripts including all grades of your previous qualifications, and a list of publications. /li /ul h3Where to apply /h3 pEmail: /p h3Work Location(s) /h3 pItalian Institute for Genomic Medicine – Candiolo, Torino, Italy (Postal Code 10060). Street SP 142 km 3.95 (address details). /p /p #J-18808-Ljbffr