Principal Scientist, Biologic Ai Research and Design

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**Site Name**: USA - Pennsylvania - Upper Providence, Cambridge MA, Italy - Siena, San Francisco, UK - Hertfordshire - Stevenage
**Posted Date**: Oct 30 2025 As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on developing, integrating, and embedding bleeding edge computational methods and predictive _in silico_ models that drive the discovery of new medicines and vaccines. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D;, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You’ll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual premio based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work. Discover more about our company wide benefits and life at GSK on our webpage _Life at GSK | GSK_ **In this role you may** - Work to generate, validate,



and integrate multimodal generative AIML models for the _de novo_ design and multi-objective optimization of tool and therapeutic biologics, such as miniproteins, antibodies, antigens, peptides, ADCs, and oligonucleotides.
- Build and exploit agent-orchestrated, integrated Design-Make-Test-Analyze cycles with automated experimental platforms, generating quality data at scale needed for project-specific and foundational models.
- Identify and advocate for the opportunities afforded by scientific computation and platform automation and driving therapeutic project plans with predictive technologies.
- Collaborate with external groups to further develop protein engineering computational methods.
- Predict and evaluate potential disease intervention points for their probability of success to be therapeutically modulated across any modality. **_ Why you?_**:
**Basic Qualifications & Skills**:
We are looking for professionals with these required skills to achieve our goals: - PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields
- Experience in protein structural or sequence analysis
- Experience in one or more programming languages (e.g. Python)
- Experience in working as team lead or member; ability to work/lead effectively in a matrix environment
- Having experience working across scientific and technical disciplines to deliver impactful solutions that drive project progression **Preferred Qualifications & Skills**:




Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: - Experience designing _de novo _binders for specified targets and epitopes to answer biological questions
- Experience with cloud engineering production-ready robust and scalable scientific workflows
- Experience building and deploying agentic workflows
- Experience analyzing NGS-derived antibody repertoires for sequence
- and structure-based design
- Experience predicting structures of RNA or nucleic acid-protein complexes
- Experience with molecular simulation and conformational analysis techniques
- Demonstrated learning agility, and scientific curiosity while maintaining focus on driving greater impact in the face of uncertainty and change
- Ability to generate conclusion reports, present data in team meetings and participate in writing of abstracts and publications for the scientific community LI-GSK Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. **Why GSK?**
**Uniting science, technology and talent to get ahead of disease together.** GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creatin

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