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Glaxosmithkline
Additional Job Description At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D; focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D;
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Job title
Principal Statistician
Location
Siena, Italy
Employment type
Permanent, Full-Time
Closing date for applications
23 August 2026
Scope
Provide stat expertise to support the different study designs.
Responsibilities
Responsible for a whole study from design to execution for different study designs: Use stat methodology to establish study strategy (e.g.power modelling of different scenarios, set up power monitoring, set up mitigation plan to minimize risk of stat failure) Provide input to protocol (design, objective, endpoint, randomization strategy, sample size, stat analysis) Provide input to study set up (CRF review, randomization, DMP plan including specification for subset, important protocol deviation) Lead or contribute to Quantitative Decision Making activities, including development of Probability of Success assessments, simulation-based evaluations, scenario analyses and other quantitative approaches that support project, governance and portfolio decisions Develop SAP/AAR (involving sensitivity analysis to support robustness of result) and coordinate review Review the TFL, to coordinate r
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