Researcher bridging immunology, genomics and proteomics

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7g72l8

Researcher bridging immunology, genomics and proteomics (academic-industry collaboration)

University of Oslo – Department of Immunology, Division of Laboratory Medicine, Institute of Clinical Medicine.

Position: Two‑year researcher (SKO 1109). Start date: July‑September 2026, flexible. Full‑time, located at GSK Vaccines S.r.l., Siena, Italy (MS Structural Biology, Ab Discovery and Immunology unit). Scientific advisor: Dr. Greiff, Lab for Computational and Systems Immunology.

The role focuses on developing an Ig‑seq platform to integrate B‑cell receptor (BCR) repertoire sequencing with serology and LC‑MS/MS proteomics for immunoproteogenomics. The candidate will design, implement, and perform experiments, data analysis, and computational modelling to link B‑cell clonotypes to serum antibodies and resolve functional proteoforms.

More about the position

Project aims: investigate polyclonal humoral responses to a model viral antigen in humans, using antigen‑specific B‑cell sorting, BCR sequencing, LC‑MS/MS identification of circulating antigen‑specific antibodies,



de‑novo sequencing workflows, proteogenomic pipelines, and machine learning for antibody identification and epitope prioritisation.

Responsibilities include development and analysis of mass spectrometry methods for antibody isolation and characterisation, designing multiparameter flow‑cytometry panels for antigen‑specific B‑cells and plasma cells, rigorous data stewardship, collaboration across immunology, proteomics, and bioinformatics teams, mainly at GSK Siena, and dissemination of research findings.

Key Duties
- BCR library preparation and sequencing workflows.
- Implementing bioinformatics pipelines for clonotyping, lineage tracing, and proteogenomic integration.
- Performing comparative analyses with published datasets.

Qualifications

Appointment requires a doctoral degree in Proteomics.
- Hands‑on experience with LC‑MS/MS method development for proteins/antibodies, including sample preparation,

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7g72l8