Oligonucleotide Design Lead
Pubblicato il 17-08-2026 - Grünenthal Group in Origgio
Professional | Permanent | Full-time | Hybrid
If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In
Research & Development
, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.
What The Job Looks Like
Every day you will enjoy different challenges such as:
- Lead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies.
- Define and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure,
cross-species alignment, and emerging experimental data
- Drive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making
- Develop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration
- Partner closely with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability, and tissue activity
- Lead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities.
What You'll Bring To The Table
To make the most of this role and truly thrive, you should have:
- PhD in RN