Researcher bridging immunology, genomics and proteomics

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7hwy1v

Researcher bridging immunology, genomics and proteomics (academic-industry collaboration)
Applicants are invited to apply for a two-year Researcher position (SKO 1109) in immuno-proteomics (hands‐on biology). The position is based at the Department of Immunology, Division of Laboratory Medicine, Institute of Clinical Medicine, University of Oslo.
The position is available from July 2026 with a flexible start date between July and September 2026. It is a full‐time role physically based at GSK Vaccines S.r.l. in Siena, Italy, within the MS Structural Biology, Ab Discovery and Immunology unit. Scientific advising and guidance will be provided by Dr. Greiff (Lab for Computational and Systems Immunology, greifflab.org).
The researcher will develop and establish an Ig‐seq platform bridging immunoglobulin profiling, B‐cell receptor (BCR) repertoire sequencing and serology.
More about the position
The proposed project aims to investigate the polyclonal humoral immune response to a model viral antigen in human samples from pre‐exposed individuals.



This research integrates advanced techniques, including antigen‐specific B‐cell sorting, B‐cell receptor (BCR) sequencing, and LC‐MS/MS‐based identification of circulating antigen‐specific antibodies. The goal is to link B‐cell clonotypes to serum immunoglobulins and resolve functional proteoforms through an immunoproteogenomics approach. The project will involve developing de novo sequencing workflows for antigen‐specific antibodies, building proteogenomic pipelines to assemble VH/VL sequences and identify clonotypes. Data will be integrated matching BCR repertoires of PBMCs, tonsil tissue, and matched sera from GSK human biological samples. Computational modeling and machine learning will be essential for antibody identification, epitope prioritization, and cross‐cohort comparisons.
The project focuses on deconvoluting pathogen‐specific humoral responses to a seasonal viral pathogen by combining paired BCR repertoire sequencing w

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7hwy1v