Postdoc Giustacchini Lab
Pubblicato il 26-08-2026 - Human Technopole in Milano
Build the science that shapes the future of human health.
Application closing date:
Join a place where ambitious science thrives
Project FIS funded by the MUR - FIS2 Consolidator CUP B53C
Project title: Tailoring precision Immunotherapy to Hematological Malignancies
Human Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health.
Within this mission, the Giustacchini group aim to develop stem-cell-based models of paediatric leukaemia to understand how malignant haematopoiesis interacts with the immune system and to improve responses to CAR T-cell therapy.
We are seeking an ambitious postdoctoral researcher to establish in vitro reprogramming and differentiation systems for modelling leukaemia-immune interactions and CAR T-cell function.
The successful candidate will combine CRISPR/Cas9-mediated gene editing, perturbation screening, high-end flow cytometry,
functional immune assays and single-cell multiomics to identify cellular and molecular determinants of therapeutic response.
This work will generate mechanistic insight into paediatric leukaemia and support the development of more effective therapeutic strategies.
Your mission
You Will Investigate The Mechanisms Governing CAR T-cell Fitness And CAR T–tumour Interactions To Understand Therapeutic Response And Resistance In Hematological Malignancies. In Particular, You Will
- Develop and apply cellular models to study CAR T–tumour interactions using CRISPR/Cas9 and complementary molecular biology approaches where appropriate.
- Design and perform flow cytometry-based immunophenotyping and functional assays to characterize CAR T-cell activation, persistence, cytotoxicity, and tumour cell responses.
- Generate high-quality functional and single-cell datasets and collaborate with computational colleagues to uncover me