Postdoctoral Researcher in Neuro Epigenetics

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7kn1j8

We are looking for a curious, creative, and driven Postdoctoral Researcher to join the research group of Mathieu Boulard at EMBL Rome to study gene regulation in neurons.

We investigate how chromatin governs olfactory receptor gene choice, an epigenetic mechanism by which olfactory neurons express a single olfactory receptor gene while repressing hundreds of unselected paralogous genes. Our approach uses a combination of mouse genetics, molecular biology, flow cytometry, microscopy, epigenomic and transcriptomic profiling, and computational genomics. Among our latest achievements is the discovery of the first factor that enforces the monogenetic transcription of olfactory receptor genes(Tabaro et al.).

Our team is located in the Epigenetics and Neurobiology Unit at EMBL Rome (located 30 min north of Rome, Italy), which offers state-of-the-art core facilities and platforms in a highly dynamic, inclusive, and multi-cultural environment.

Your role




You will play a central role in the exploration of the molecular logic of allelic exclusion using the paradigm of olfactory receptor gene choice. A central goal of the project is to profile chromatin and transcription in subpopulations of olfactory sensory neurons.
This project will be a team effort with other lab members working on related aspects, having generated preliminary results and having developed experimental tools.
The position is ideal for a scientist interested in neuro-epigenetics.

You have
- A PhD in life science.
- A strong interest in functional genome biology and/or molecular neuroscience.
- Expertise in one of the following is essential: chromatin biology and/or mouse genetics.
- Hands-on in vivo experience with mouse models or another model organism.
- Experience with transcriptomics and epigenomic profiling (RNA-seq, Cut&run;).
- Ability to work independently while contributing to a collaborative team.
- Excellent communication and interpersonal skills with the highest ethical standards.

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Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/7kn1j8