Computational Postdoc- Giustacchini Group
Pubblicato il 03-09-2026 - Human Technopole in Milano
ph3Build the science that shapes the future of human health. /h3 pApplication closing date: /p h3FUNDED by Start up grant Fondazione AIRC /h3 h3Join a place where ambitious science thrives /h3 pHuman Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health. /p pWithin this mission, the Giustacchini group investigates how leukaemia and the immune system interact to shape treatment response, with a particular focus on CAR T-cell fitness. In collaboration with Professor Persis Amrolia at University College London (UCL), we combine longitudinal clinical samples, single-cell multiomics and computational modelling to identify mechanisms that can improve cellular immunotherapies for paediatric leukaemia. /p h3Your mission /h3 pYou Will Develop a Computational Programme To Define How CAR T-cell Intrinsic States And Bidirectional Interactions With Leukaemia And The Immune Microenvironment Shape Therapeutic Response. In Particular, You Will /p ul liDevelop computational workflows for the analysis and integration of longitudinal single-cell and multiomic datasets from multiple CAR T-cell clinical studies, encompassing different CAR designs and targeting strategies. /li liCharacterise CAR T-cell composition, activation, differentiation, fitness, expansion, persistence and dysfunction, integrating RNA, surface-protein, CAR-detection, and clinical information. /li liResolve bidirectional CAR T-leukaemia and immune-cell crosstalk,
linking CAR T-cell states to tumour and immune composition at matched time points to identify mechanisms of response, resistance and persistence for functional validation. /li liLead the interpretation of complex datasets and contribute to manuscripts, grant applications and collaborative translational studies with clinical and academic partners. /li /ul h3Grow Your Skills /h3 pThe successful candidate will join a multidisciplinary team of computational biologists, immunologists and experimental researchers within the Population and Medical Genomics Centre. The project will be developed in close collaboration with Professor Persis Amrolia and colleagues at UCL, who lead the associated CAR T-cell clinical studies and provide access to unique longitudinal patient samples and clinical expertise. The role will vantaggi from Human Technopole infrastructure in single-cell genomics, computational biology, data science and high-performance computing, alongside direct interaction with colleagues performing functional CAR T-cell studies. /p pHuman Technopole supports career development through training, mentoring and dedicated learning opportunities. /p h3Essential /h3 pWhat you'll bring /p ul liPhD in computational biology, bioinformatics, biostatistics, systems biology, immunology with a strong computational component, or a related discipline (thesis at least submitted).
/li liDemonstrated experience analysing single-cell RNA-seq data, including cell-state annotation, differential expression, pathway analysis and biological interpretation. /li liStrong proficiency in R and/or Python /li liAbility to work collaboratively across computational, experimental and clinical disciplines while independently driving a research project. /li /ul h3Preferred /h3 ul liExperience analysing multimodal and longitudinal single-cell data, such as CITE-seq, immune-receptor repertoires, CAR transgene/detection data or paired transcriptomic and protein measurements. /li liKnowledge of T-cell and CAR T-cell biology, tumour immunology, haematological malignancies or immune-tumour interactions. /li liExperience with longitudinal clinical cohorts, trajectory or clonal analyses, cell-cell communication methods, or integration of molecular and clinical outcome data. /li /ul h3At HT, your discoveries contribute to a global effort to improve human health. /h3 h3Why Human Technopole /h3 pHT offers an international and dynamic workplace, competitive welfare provisions, flexible working policies and relocation support. Researchers moving to Italy may benefit from attractive tax benefits. We promote work–life balance and provide parental support initiatives. /p pThis is a 3-year contract (linked to the duration of the grant), offered under CCNL Chimico Farmaceutico, Level B2. /p pSalary: up to € 43.000,00 depending on the candidate' seniority. /p pThe position is based in Milan, Italy, within our vibrant international campus. /p pWe strongly encourage applications from candidates belonging to protected categories (L. 68/99). /p /p #J-18808-Ljbffr