Formulations For Topic Mucosal And/Or Oral Systemic Administrations Containing A Mixture Based On La

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/83r2cg

Organisation/Company Microbo s.r.l. Research Field Biological sciences » Other Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 1 Oct *********:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description The project aims to evaluate the efficacy of bovine lactoferrin (bLf) and the Valpalf® formulation, prepared
by combining bLf with sodium citrate and sodium bicarbonate, in in vitro models of inflammatory bowel
diseases. Caco-2 cells and THP-1 cells differentiated into macrophages will be used to simulate enterocytes




and immune response, respectively. Experimental models will reproduce ulcerative colitis
(lipopolysaccharide stimulation) and Crohn's disease (interferon-? stimulation and infection with an E. coli
bacterial strain). The project will analyze the effects of treatments on bacterial invasion and survival,
inflammation, oxidative stress, and iron homeostasis, in order to clarify the therapeutic potential of
lactoferrin in its two formulations, standard and Valpalf®.
Italy
Eligibility of fellows: country/ies of residence:
OTHER
Eligibility of fellows: nationality/ies:

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/83r2cg