PhD Position

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/8czqay

Organisation/Company Università degli Studi di Perugia Department Department of Medicine and Surgery Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 8 Nov 2026 - 13:00 (Europe/Rome) Country Italy Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Horizon Europe - MSCA Marie Curie Grant Agreement Number 101311007 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

DC12 will develop novel prognostic and predictive markers for mucosal melanoma (MuM) by integrating multi-omics and spatial analyses of MuM tissues. The project will apply WP1 multi-omics approaches, WP2 spatial multi-omics methods and WP3 computational algorithms to map melanoma phenotypes, immune cell subsets and their spatial organisation. It pursues two integrated objectives: i) refine prognostic markers for MuM; and ii) identify multiparametric predictive and spatial biomarker signatures with potential clinical relevance.



Working with EORTC melanoma centres, the project will also investigate immune-suppressive pathways and treatment-driven mechanisms of immune tolerance.

At the University of Perugia, the candidate will analyse genomic profiling of tumour samples and correlate findings with prognostic parameters to refine the prognostic value of genomic features and to the identification of predictive biomarkers. During a first secondment at Bosisio’s Lab the candidate will be able to study single cell and transcriptomic analysis, the candidate as well as training in spatial analyses and translational immune-oncology approaches. A second secondment at IB for spatial analysis (2nd secondment). Expected results: (1) Predictive tissue-based biomarkers; (2) Functional studies of tolerogenic immune cells; (3) Identification of treatment-driven immune tolerance mechanisms.

Requirements

Research Field Biological science

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/8czqay