Research Fellow

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/8gqxqx

A Research Fellow position is immediately available under the supervision of Michela Milani, Project Leader in the group led by Alessio Cantore at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy (https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy/liver-gene-therapy.html)
The Institute. SR-Tiget was created in 1996 as a joint venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting-edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases. The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university, and also hosts several biotechnology companies.
Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses,



and innate immune cells in cancer. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated >140 patients and led to the filing and approval of 2 novel advanced therapy medicines.
The position. We are looking for a motivated Research Fellow to work on an exciting new project aiming at developing an innovative in vivo lentiviral vector gene therapy strategy for hemophilia A. In particular, we will develop different lentiviral vectors encoding an engineered version of human factor VIII (FVIII) transgene under the control of different megakaryocyte-specific promoters. These vectors will be tested in vitro and in vivo in hemophilia A mouse models to select the best candidate to achieve effective FVIII expression in platelets after in vivo ge

Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/8gqxqx