Study Of Mitochondrial Transfer Into Thermogenic Tissues During Aging

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Organisation/Company Università degli Studi di Roma Tor Vergata - Dipartimento di Biologia Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 31 Oct *********:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Aging undermines the body's ability to adapt, particularly the function of thermogenic adipose tissue (t-AT), which is essential for metabolism.
As we age, the quality of mitochondria declines,



leading to metabolic disorders like insulin resistance and type 2 diabetes When adipocytes are stressed, they release damaged mitochondria that are quickly cleared by macrophages.
These
immune cells transform into "M2" macrophages, which have anti-inflammatory properties.
Recent discoveries
indicate that M2 macrophages can transfer their healthy mitochondria to adipocytes, providing bioenergetic support.
The hypothesis is that with aging, this virtuous cycle is disrupted, accelerating metabolic decline and aggravating
age-related diseases
Italy
Eligibility of fellows: country/ies of residence:
OTHER
Eligibility of fellows: nationality/ies:
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Vedi l’offerta su Go Lavoro: golavoro.it/annuncio-lavoro/8nji6i