Computational Hemoglobin Allosteric Modulator Discovery
Dipartimento di Chimica e tecnologie del farmaco in Italy seeks a research fellow to develop computational models for selecting novel hemoglobin allosteric modulators. The project uses virtual binding studies to identify compounds with hemoglobin inhibitory activity and plans optimization through virtual screening and chemical synthesis.
Selected candidates will be re-evaluated for activity on hemoglobin, with lead compounds tested on erythrocytes from sickle cell patients.
Selected candidates will be re-evaluated for activity on hemoglobin, with lead compounds tested on erythrocytes from sickle cell patients.